Super-Enhancer Transcription Converges on AID

: Alinikula J, Schatz DG

Publisher: CELL PRESS

: 2014

: Cell

: CELL

: 159

: 7

: 1490

: 1492

: 3

: 0092-8674

DOI: https://doi.org/10.1016/j.cell.2014.12.007

AID mis-targeting is poorly understood but contributes significantly to B cell genome instability. Two new papers in Cell reveal that AID mistargeting occurs primarily in gene bodies within a nuclear microenvironment characterized by high levels of transcriptional activity, interconnected transcriptional regulatory elements, and overlapping sense and antisense (convergent) transcription.