A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Super-Enhancer Transcription Converges on AID
Tekijät: Alinikula J, Schatz DG
Kustantaja: CELL PRESS
Julkaisuvuosi: 2014
Journal: Cell
Tietokannassa oleva lehden nimi: CELL
Lehden akronyymi: CELL
Vuosikerta: 159
Numero: 7
Aloitussivu: 1490
Lopetussivu: 1492
Sivujen määrä: 3
ISSN: 0092-8674
DOI: https://doi.org/10.1016/j.cell.2014.12.007
Tiivistelmä
AID mis-targeting is poorly understood but contributes significantly to B cell genome instability. Two new papers in Cell reveal that AID mistargeting occurs primarily in gene bodies within a nuclear microenvironment characterized by high levels of transcriptional activity, interconnected transcriptional regulatory elements, and overlapping sense and antisense (convergent) transcription.
AID mis-targeting is poorly understood but contributes significantly to B cell genome instability. Two new papers in Cell reveal that AID mistargeting occurs primarily in gene bodies within a nuclear microenvironment characterized by high levels of transcriptional activity, interconnected transcriptional regulatory elements, and overlapping sense and antisense (convergent) transcription.
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