A2 Refereed review article in a scientific journal

Super-Enhancer Transcription Converges on AID



Authors: Alinikula J, Schatz DG

Publisher: CELL PRESS

Publication year: 2014

Journal: Cell

Journal name in source: CELL

Journal acronym: CELL

Volume: 159

Issue: 7

First page : 1490

Last page: 1492

Number of pages: 3

ISSN: 0092-8674

DOI: https://doi.org/10.1016/j.cell.2014.12.007


Abstract
AID mis-targeting is poorly understood but contributes significantly to B cell genome instability. Two new papers in Cell reveal that AID mistargeting occurs primarily in gene bodies within a nuclear microenvironment characterized by high levels of transcriptional activity, interconnected transcriptional regulatory elements, and overlapping sense and antisense (convergent) transcription.



Last updated on 2024-26-11 at 15:27