The emergence of genotypes 3 and 4 hepatitis E virus in swine and humans: a phylogenetic perspective



: Xia HY, Wahlberg N, Belak S, Meng XJ, Liu LH

Publisher: SPRINGER WIEN

: 2011

: Archives of Virology

: ARCHIVES OF VIROLOGY

: ARCH VIROL

: 1

: 156

: 1

: 121

: 124

: 4

: 0304-8608

DOI: https://doi.org/10.1007/s00705-010-0818-6


To investigate whether there is any phylogenetic evidence to support the hypothesis that swine is the natural host of HEV genotypes 3 and 4, Bayesian analysis of 80 full-length genomic sequences of HEV was performed. The results showed that the strains of genotypes 3 and 4 from swine are paraphyletic with regard to strains of human origin, which are thus phylogenetically nested among the swine strains. Recognition of HEV genotypes 3 and 4 as viruses from swine or swine HEV can provide an evolutionary explanation to the observation of cross-species infection by genotypes 3 and 4 HEV.



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