A1 Refereed original research article in a scientific journal
The emergence of genotypes 3 and 4 hepatitis E virus in swine and humans: a phylogenetic perspective
Authors: Xia HY, Wahlberg N, Belak S, Meng XJ, Liu LH
Publisher: SPRINGER WIEN
Publication year: 2011
Journal: Archives of Virology
Journal name in source: ARCHIVES OF VIROLOGY
Journal acronym: ARCH VIROL
Number in series: 1
Volume: 156
Issue: 1
First page : 121
Last page: 124
Number of pages: 4
ISSN: 0304-8608
DOI: https://doi.org/10.1007/s00705-010-0818-6(external)
Abstract
To investigate whether there is any phylogenetic evidence to support the hypothesis that swine is the natural host of HEV genotypes 3 and 4, Bayesian analysis of 80 full-length genomic sequences of HEV was performed. The results showed that the strains of genotypes 3 and 4 from swine are paraphyletic with regard to strains of human origin, which are thus phylogenetically nested among the swine strains. Recognition of HEV genotypes 3 and 4 as viruses from swine or swine HEV can provide an evolutionary explanation to the observation of cross-species infection by genotypes 3 and 4 HEV.
To investigate whether there is any phylogenetic evidence to support the hypothesis that swine is the natural host of HEV genotypes 3 and 4, Bayesian analysis of 80 full-length genomic sequences of HEV was performed. The results showed that the strains of genotypes 3 and 4 from swine are paraphyletic with regard to strains of human origin, which are thus phylogenetically nested among the swine strains. Recognition of HEV genotypes 3 and 4 as viruses from swine or swine HEV can provide an evolutionary explanation to the observation of cross-species infection by genotypes 3 and 4 HEV.
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