Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder



: Streng T, Axelsson HE, Hedlund P, Andersson DA, Jordt SE, Bevan S, Andersson KE, Hogestatt ED, Zygmunt PM

Publisher: ELSEVIER SCIENCE BV

: 2008

European Urology

EUROPEAN UROLOGY

: EUR UROL

: 53

: 2

: 391

: 399

: 9

: 0302-2838

DOI: https://doi.org/10.1016/j.eururo.2007.10.024


Conclusions: The expression of TRPA1 on C-fibre bladder afferents and urothelial cells together with the finding that intravesical TRPA1 activators initiate detrusor overactivity indicate that TRPA1 may have a role in sensory transduction in this organ. The study also highlights H2S as a TRPA1 activator potentially involved in inflammatory bladder disease. (c) 2007 Published by Elsevier B.V. on behalf of European Association of Urology.



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