Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder



: Streng T, Axelsson HE, Hedlund P, Andersson DA, Jordt SE, Bevan S, Andersson KE, Hogestatt ED, Zygmunt PM

Publisher: ELSEVIER SCIENCE BV

: 2008

 European Urology

: EUROPEAN UROLOGY

: EUR UROL

: 53

: 2

: 391

: 399

: 9

: 0302-2838

DOI: https://doi.org/10.1016/j.eururo.2007.10.024


Conclusions: The expression of TRPA1 on C-fibre bladder afferents and urothelial cells together with the finding that intravesical TRPA1 activators initiate detrusor overactivity indicate that TRPA1 may have a role in sensory transduction in this organ. The study also highlights H2S as a TRPA1 activator potentially involved in inflammatory bladder disease. (c) 2007 Published by Elsevier B.V. on behalf of European Association of Urology.


cystometry, hydrogen sulfide, ion channels, micturition, rat, sensory neurons, transient receptor potential, TRPA1, TRPV1, urinary bladder, urothelium



Last updated on 14/10/2025 10:10:03 AM