A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder
Tekijät: Streng T, Axelsson HE, Hedlund P, Andersson DA, Jordt SE, Bevan S, Andersson KE, Hogestatt ED, Zygmunt PM
Kustantaja: ELSEVIER SCIENCE BV
Julkaisuvuosi: 2008
Lehti:European Urology
Tietokannassa oleva lehden nimiEUROPEAN UROLOGY
Lehden akronyymi: EUR UROL
Vuosikerta: 53
Numero: 2
Aloitussivu: 391
Lopetussivu: 399
Sivujen määrä: 9
ISSN: 0302-2838
DOI: https://doi.org/10.1016/j.eururo.2007.10.024
Tiivistelmä
Conclusions: The expression of TRPA1 on C-fibre bladder afferents and urothelial cells together with the finding that intravesical TRPA1 activators initiate detrusor overactivity indicate that TRPA1 may have a role in sensory transduction in this organ. The study also highlights H2S as a TRPA1 activator potentially involved in inflammatory bladder disease. (c) 2007 Published by Elsevier B.V. on behalf of European Association of Urology.
Conclusions: The expression of TRPA1 on C-fibre bladder afferents and urothelial cells together with the finding that intravesical TRPA1 activators initiate detrusor overactivity indicate that TRPA1 may have a role in sensory transduction in this organ. The study also highlights H2S as a TRPA1 activator potentially involved in inflammatory bladder disease. (c) 2007 Published by Elsevier B.V. on behalf of European Association of Urology.
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