A1 Refereed original research article in a scientific journal
Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder
Authors: Streng T, Axelsson HE, Hedlund P, Andersson DA, Jordt SE, Bevan S, Andersson KE, Hogestatt ED, Zygmunt PM
Publisher: ELSEVIER SCIENCE BV
Publication year: 2008
Journal:European Urology
Journal name in sourceEUROPEAN UROLOGY
Journal acronym: EUR UROL
Volume: 53
Issue: 2
First page : 391
Last page: 399
Number of pages: 9
ISSN: 0302-2838
DOI: https://doi.org/10.1016/j.eururo.2007.10.024
Abstract
Conclusions: The expression of TRPA1 on C-fibre bladder afferents and urothelial cells together with the finding that intravesical TRPA1 activators initiate detrusor overactivity indicate that TRPA1 may have a role in sensory transduction in this organ. The study also highlights H2S as a TRPA1 activator potentially involved in inflammatory bladder disease. (c) 2007 Published by Elsevier B.V. on behalf of European Association of Urology.
Conclusions: The expression of TRPA1 on C-fibre bladder afferents and urothelial cells together with the finding that intravesical TRPA1 activators initiate detrusor overactivity indicate that TRPA1 may have a role in sensory transduction in this organ. The study also highlights H2S as a TRPA1 activator potentially involved in inflammatory bladder disease. (c) 2007 Published by Elsevier B.V. on behalf of European Association of Urology.
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