NUCLEOTIDE-SEQUENCES AND EXPRESSION OF GENES FROM STREPTOMYCES-PURPURASCENS THAT CAUSE THE PRODUCTION OF NEW ANTHRACYCLINES IN STREPTOMYCES-GALILAEUS



: NIEMI J, MANTSALA P

Publisher: AMER SOC MICROBIOLOGY

: 1995

Journal of Bacteriology

JOURNAL OF BACTERIOLOGY

: J BACTERIOL

: 177

: 10

: 2942

: 2945

: 4

: 0021-9193

DOI: https://doi.org/10.1128/jb.177.10.2942-2945.1995


Six open reading frames, rdmA to rdmF, in a 6,077-bp segment of Streptomyces purpurascens DNA which caused the production of hybrid anthracyclines were identified. The minimal fragment that produced anthracyclines modified at the 10th position contained rdmB to rdmD; rdmE is the gene for aklavinone-11-hydroxylase. RdmC is similar to a putative open reading frame in the daunorubicin biosynthetic cluster of Streptomyces peucetius and is likely to participate in the removal of the side chain at the 10th position.



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