A1 Refereed original research article in a scientific journal
NUCLEOTIDE-SEQUENCES AND EXPRESSION OF GENES FROM STREPTOMYCES-PURPURASCENS THAT CAUSE THE PRODUCTION OF NEW ANTHRACYCLINES IN STREPTOMYCES-GALILAEUS
Authors: NIEMI J, MANTSALA P
Publisher: AMER SOC MICROBIOLOGY
Publication year: 1995
Journal:: Journal of Bacteriology
Journal name in source: JOURNAL OF BACTERIOLOGY
Journal acronym: J BACTERIOL
Volume: 177
Issue: 10
First page : 2942
Last page: 2945
Number of pages: 4
ISSN: 0021-9193
DOI: https://doi.org/10.1128/jb.177.10.2942-2945.1995
Abstract
Six open reading frames, rdmA to rdmF, in a 6,077-bp segment of Streptomyces purpurascens DNA which caused the production of hybrid anthracyclines were identified. The minimal fragment that produced anthracyclines modified at the 10th position contained rdmB to rdmD; rdmE is the gene for aklavinone-11-hydroxylase. RdmC is similar to a putative open reading frame in the daunorubicin biosynthetic cluster of Streptomyces peucetius and is likely to participate in the removal of the side chain at the 10th position.
Six open reading frames, rdmA to rdmF, in a 6,077-bp segment of Streptomyces purpurascens DNA which caused the production of hybrid anthracyclines were identified. The minimal fragment that produced anthracyclines modified at the 10th position contained rdmB to rdmD; rdmE is the gene for aklavinone-11-hydroxylase. RdmC is similar to a putative open reading frame in the daunorubicin biosynthetic cluster of Streptomyces peucetius and is likely to participate in the removal of the side chain at the 10th position.
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