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NUCLEOTIDE-SEQUENCES AND EXPRESSION OF GENES FROM STREPTOMYCES-PURPURASCENS THAT CAUSE THE PRODUCTION OF NEW ANTHRACYCLINES IN STREPTOMYCES-GALILAEUS
Tekijät: NIEMI J, MANTSALA P
Kustantaja: AMER SOC MICROBIOLOGY
Julkaisuvuosi: 1995
Lehti:: Journal of Bacteriology
Tietokannassa oleva lehden nimi: JOURNAL OF BACTERIOLOGY
Lehden akronyymi: J BACTERIOL
Vuosikerta: 177
Numero: 10
Aloitussivu: 2942
Lopetussivu: 2945
Sivujen määrä: 4
ISSN: 0021-9193
DOI: https://doi.org/10.1128/jb.177.10.2942-2945.1995
Tiivistelmä
Six open reading frames, rdmA to rdmF, in a 6,077-bp segment of Streptomyces purpurascens DNA which caused the production of hybrid anthracyclines were identified. The minimal fragment that produced anthracyclines modified at the 10th position contained rdmB to rdmD; rdmE is the gene for aklavinone-11-hydroxylase. RdmC is similar to a putative open reading frame in the daunorubicin biosynthetic cluster of Streptomyces peucetius and is likely to participate in the removal of the side chain at the 10th position.
Six open reading frames, rdmA to rdmF, in a 6,077-bp segment of Streptomyces purpurascens DNA which caused the production of hybrid anthracyclines were identified. The minimal fragment that produced anthracyclines modified at the 10th position contained rdmB to rdmD; rdmE is the gene for aklavinone-11-hydroxylase. RdmC is similar to a putative open reading frame in the daunorubicin biosynthetic cluster of Streptomyces peucetius and is likely to participate in the removal of the side chain at the 10th position.
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