A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Metabolic signatures of birthweight in 18 288 adolescents and adults.
Tekijät: Würtz P, Wang Q, Niironen M, Tynkkynen T, Tiainen M, Drenos F, Kangas AJ, Soininen P, Skilton MR, Heikkilä K, Pouta A, Kähönen M, Lehtimäki T, Rose RJ, Kajantie E, Perola M, Kaprio J, Eriksson JG, Raitakari OT, Lawlor DA, Davey Smith G, Järvelin MR, Ala-Korpela M, Auro K
Julkaisuvuosi: 2016
Journal: International Journal of Epidemiology
Vuosikerta: 45
Numero: 5
Aloitussivu: 1539
Lopetussivu: 1550
Sivujen määrä: 12
ISSN: 0300-5771
DOI: https://doi.org/10.1093/ije/dyw255
Verkko-osoite: https://doi.org/10.1093/ije/dyw255
Conclusions: Lower birthweight adjusted for gestational age is associated with adverse biomarker aberrations across multiple metabolic pathways. Coherent metabolic signatures between lower birthweight and higher adult adiposity suggest that shared molecular pathways may potentially underpin the metabolic deviations. However, the magnitudes of metabolic associations with birthweight are modest in comparison to the effects of adiposity, implying that birthweight is only a weak indicator of the metabolic risk profile in adulthood.
