A1 Refereed original research article in a scientific journal

Metabolic signatures of birthweight in 18 288 adolescents and adults.



Authors: Würtz P, Wang Q, Niironen M, Tynkkynen T, Tiainen M, Drenos F, Kangas AJ, Soininen P, Skilton MR, Heikkilä K, Pouta A, Kähönen M, Lehtimäki T, Rose RJ, Kajantie E, Perola M, Kaprio J, Eriksson JG, Raitakari OT, Lawlor DA, Davey Smith G, Järvelin MR, Ala-Korpela M, Auro K

Publication year: 2016

Journal: International Journal of Epidemiology

Volume: 45

Issue: 5

First page : 1539

Last page: 1550

Number of pages: 12

ISSN: 0300-5771

DOI: https://doi.org/10.1093/ije/dyw255

Web address : https://doi.org/10.1093/ije/dyw255


Abstract

Conclusions: Lower birthweight adjusted for gestational age is associated with adverse biomarker aberrations across multiple metabolic pathways. Coherent metabolic signatures between lower birthweight and higher adult adiposity suggest that shared molecular pathways may potentially underpin the metabolic deviations. However, the magnitudes of metabolic associations with birthweight are modest in comparison to the effects of adiposity, implying that birthweight is only a weak indicator of the metabolic risk profile in adulthood.



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