B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
Dimeric IgA specifically disables intracellular mutated oncodrivers
Tekijät: Prince Stuart, Hollmén Maija
Julkaisuvuosi: 2023
Journal: Immunity
Tietokannassa oleva lehden nimi: Immunity
Lehden akronyymi: Immunity
Vuosikerta: 56
Numero: 11
Aloitussivu: 2461
Lopetussivu: 2463
ISSN: 1074-7613
eISSN: 1097-4180
DOI: https://doi.org/10.1016/j.immuni.2023.10.014
Verkko-osoite: https://doi.org/10.1016/j.immuni.2023.10.014
Tiivistelmä
A prevailing belief in the immunotherapy field has been that antibody therapy can effectively target only extracellular antigens. In this issue of Immunity, Biswas et al. demonstrate therapeutically effective targeting, neutralization, and removal of mutated oncodriver proteins from within epithelial cancer cells by treatment with pIgR-dependent, transcytosing dimeric-IgA antibodies.
A prevailing belief in the immunotherapy field has been that antibody therapy can effectively target only extracellular antigens. In this issue of Immunity, Biswas et al. demonstrate therapeutically effective targeting, neutralization, and removal of mutated oncodriver proteins from within epithelial cancer cells by treatment with pIgR-dependent, transcytosing dimeric-IgA antibodies.
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