B1 Non-refereed article in a scientific journal

Dimeric IgA specifically disables intracellular mutated oncodrivers



Authors: Prince Stuart, Hollmén Maija

Publication year: 2023

Journal: Immunity

Journal name in source: Immunity

Journal acronym: Immunity

Volume: 56

Issue: 11

First page : 2461

Last page: 2463

ISSN: 1074-7613

eISSN: 1097-4180

DOI: https://doi.org/10.1016/j.immuni.2023.10.014

Web address : https://doi.org/10.1016/j.immuni.2023.10.014


Abstract
A prevailing belief in the immunotherapy field has been that antibody therapy can effectively target only extracellular antigens. In this issue of Immunity, Biswas et al. demonstrate therapeutically effective targeting, neutralization, and removal of mutated oncodriver proteins from within epithelial cancer cells by treatment with pIgR-dependent, transcytosing dimeric-IgA antibodies.



Last updated on 2025-27-03 at 22:01