A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Prognostic Significance of Tumor-associated Stroma in Nasopharyngeal Carcinoma: A Multicenter Study
Tekijät: Almangush, Alhadi; Ruuskanen, Miia; Hagström, Jaana; Kosma, Veli-Matti; Nieminen, Pentti; Mäkitie, Antti A; Leivo, Ilmo
Julkaisuvuosi: 2024
Journal: American Journal of Surgical Pathology
Tietokannassa oleva lehden nimi: The American journal of surgical pathology
Lehden akronyymi: Am J Surg Pathol
Vuosikerta: 48
Numero: 1
Aloitussivu: 54
Lopetussivu: 58
ISSN: 0147-5185
eISSN: 1532-0979
DOI: https://doi.org/10.1097/PAS.0000000000002137
Verkko-osoite: https://journals.lww.com/ajsp/fulltext/2024/01000/prognostic_significance_of_tumor_associated_stroma.11.aspx
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/181774195
Assessment of tumor-associated stroma has shown a reliable prognostic value in recent research. We evaluated the prognostic value of tumor-stroma ratio (TSR) in a large multicenter cohort of nasopharyngeal carcinoma (NPC). We used the conventional hematoxylin and eosin-stained slides of 115 cases of NPC to assess TSR as described in recent guidelines. The amount of tumor-associated stroma was assessed as a percentage and then tumors were classified as stroma-high (>50%) or stroma-low (≤50%). Kaplan-Meier curves, χ2 test, and Cox regression univariable and multivariable analyses were carried out. A total of 48 (41.7%) tumors were stroma-high and 67 (58.3%) tumors were stroma-low. In the Cox regression multivariable analysis, the tumors categorized as stroma-high were associated with a worse overall survival with a hazard ratio of 2.30 (95% CI: 1.27-4.15, P=0.006) and with poor disease-specific survival (hazard ratio=1.87, 95% CI: 1.07-3.28, P=0.029). The assessment of TSR in NPC is simple and cost-effective, and it has a significant prognostic value. TSR can aid in risk stratification and clinical decision-making in NPC.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
