A1 Refereed original research article in a scientific journal
Prognostic Significance of Tumor-associated Stroma in Nasopharyngeal Carcinoma: A Multicenter Study
Authors: Almangush, Alhadi; Ruuskanen, Miia; Hagström, Jaana; Kosma, Veli-Matti; Nieminen, Pentti; Mäkitie, Antti A; Leivo, Ilmo
Publication year: 2024
Journal: American Journal of Surgical Pathology
Journal name in source: The American journal of surgical pathology
Journal acronym: Am J Surg Pathol
Volume: 48
Issue: 1
First page : 54
Last page: 58
ISSN: 0147-5185
eISSN: 1532-0979
DOI: https://doi.org/10.1097/PAS.0000000000002137(external)
Web address : https://journals.lww.com/ajsp/fulltext/2024/01000/prognostic_significance_of_tumor_associated_stroma.11.aspx(external)
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/181774195(external)
Assessment of tumor-associated stroma has shown a reliable prognostic value in recent research. We evaluated the prognostic value of tumor-stroma ratio (TSR) in a large multicenter cohort of nasopharyngeal carcinoma (NPC). We used the conventional hematoxylin and eosin-stained slides of 115 cases of NPC to assess TSR as described in recent guidelines. The amount of tumor-associated stroma was assessed as a percentage and then tumors were classified as stroma-high (>50%) or stroma-low (≤50%). Kaplan-Meier curves, χ2 test, and Cox regression univariable and multivariable analyses were carried out. A total of 48 (41.7%) tumors were stroma-high and 67 (58.3%) tumors were stroma-low. In the Cox regression multivariable analysis, the tumors categorized as stroma-high were associated with a worse overall survival with a hazard ratio of 2.30 (95% CI: 1.27-4.15, P=0.006) and with poor disease-specific survival (hazard ratio=1.87, 95% CI: 1.07-3.28, P=0.029). The assessment of TSR in NPC is simple and cost-effective, and it has a significant prognostic value. TSR can aid in risk stratification and clinical decision-making in NPC.
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