Altered Regulation of ELAVL1/HuR in HLA-B27-Expressing U937 Monocytic Cells

: Sahlberg AS, Ruuska M, Granfors K, Penttinen MA

Publisher: PUBLIC LIBRARY SCIENCE

: 2013

: PLoS ONE

: PLOS ONE

: ARTN e70377

: 7

: 8

: 7

: 12

: 1932-6203

DOI: https://doi.org/10.1371/journal.pone.0070377

Conclusion: Results show that the expression of HLA-B27 HCs modulates the intracellular environment of U937 monocyte/macrophages by altering HuR regulation. This phenomenon is at least partly dependent on the misfolding feature of the B27 molecule. Since HuR is an important regulator of multiple genes involved in inflammatory response observations offer an explanation how HLA-B27 may modulate inflammatory response.