A1 Refereed original research article in a scientific journal
Altered Regulation of ELAVL1/HuR in HLA-B27-Expressing U937 Monocytic Cells
Authors: Sahlberg AS, Ruuska M, Granfors K, Penttinen MA
Publisher: PUBLIC LIBRARY SCIENCE
Publication year: 2013
Journal: PLoS ONE
Journal name in source: PLOS ONE
Journal acronym: PLOS ONE
Article number: ARTN e70377
Number in series: 7
Volume: 8
Issue: 7
Number of pages: 12
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0070377
Abstract
Conclusion: Results show that the expression of HLA-B27 HCs modulates the intracellular environment of U937 monocyte/macrophages by altering HuR regulation. This phenomenon is at least partly dependent on the misfolding feature of the B27 molecule. Since HuR is an important regulator of multiple genes involved in inflammatory response observations offer an explanation how HLA-B27 may modulate inflammatory response.
Conclusion: Results show that the expression of HLA-B27 HCs modulates the intracellular environment of U937 monocyte/macrophages by altering HuR regulation. This phenomenon is at least partly dependent on the misfolding feature of the B27 molecule. Since HuR is an important regulator of multiple genes involved in inflammatory response observations offer an explanation how HLA-B27 may modulate inflammatory response.
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