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Altered Regulation of ELAVL1/HuR in HLA-B27-Expressing U937 Monocytic Cells
Tekijät: Sahlberg AS, Ruuska M, Granfors K, Penttinen MA
Kustantaja: PUBLIC LIBRARY SCIENCE
Julkaisuvuosi: 2013
Journal: PLoS ONE
Tietokannassa oleva lehden nimi: PLOS ONE
Lehden akronyymi: PLOS ONE
Artikkelin numero: ARTN e70377
Numero sarjassa: 7
Vuosikerta: 8
Numero: 7
Sivujen määrä: 12
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0070377
Tiivistelmä
Conclusion: Results show that the expression of HLA-B27 HCs modulates the intracellular environment of U937 monocyte/macrophages by altering HuR regulation. This phenomenon is at least partly dependent on the misfolding feature of the B27 molecule. Since HuR is an important regulator of multiple genes involved in inflammatory response observations offer an explanation how HLA-B27 may modulate inflammatory response.
Conclusion: Results show that the expression of HLA-B27 HCs modulates the intracellular environment of U937 monocyte/macrophages by altering HuR regulation. This phenomenon is at least partly dependent on the misfolding feature of the B27 molecule. Since HuR is an important regulator of multiple genes involved in inflammatory response observations offer an explanation how HLA-B27 may modulate inflammatory response.
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