B1 Non-refereed article in a scientific journal
Response to Letter to the Editor
Authors: Cajander Per, Omari Taher, Scheinin Harry, Scheinin Mika, Savilampi Johanna
Publisher: WILEY
Publication year: 2023
Journal: Neurogastroenterology and Motility
Journal name in source: NEUROGASTROENTEROLOGY AND MOTILITY
Journal acronym: NEUROGASTROENT MOTIL
Article number: e14616
Volume: 35
Issue: 8
Number of pages: 2
eISSN: 1365-2982
DOI: https://doi.org/10.1111/nmo.14616
Web address : https://onlinelibrary.wiley.com/doi/10.1111/nmo.14616
Abstract
It is crucial to consider the possible influence of anesthetic agents on esophageal function testing. Dexmedetomidine has been shown to affect primary peristalsis during esophageal manometry. In the two case reports presented by Toaz et al., secondary peristalsis during FLIP panometry was also affected. This may be attributed to an alternate pharmacodynamic effect, with a transient direct alpha 2-mediated effect on esophageal smooth muscle, associated with a high plasma concentration following bolus injection, prior to the onset of sympathetic inhibition.
It is crucial to consider the possible influence of anesthetic agents on esophageal function testing. Dexmedetomidine has been shown to affect primary peristalsis during esophageal manometry. In the two case reports presented by Toaz et al., secondary peristalsis during FLIP panometry was also affected. This may be attributed to an alternate pharmacodynamic effect, with a transient direct alpha 2-mediated effect on esophageal smooth muscle, associated with a high plasma concentration following bolus injection, prior to the onset of sympathetic inhibition.
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