B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
Response to Letter to the Editor
Tekijät: Cajander Per, Omari Taher, Scheinin Harry, Scheinin Mika, Savilampi Johanna
Kustantaja: WILEY
Julkaisuvuosi: 2023
Journal: Neurogastroenterology and Motility
Tietokannassa oleva lehden nimi: NEUROGASTROENTEROLOGY AND MOTILITY
Lehden akronyymi: NEUROGASTROENT MOTIL
Artikkelin numero: e14616
Vuosikerta: 35
Numero: 8
Sivujen määrä: 2
eISSN: 1365-2982
DOI: https://doi.org/10.1111/nmo.14616
Verkko-osoite: https://onlinelibrary.wiley.com/doi/10.1111/nmo.14616
Tiivistelmä
It is crucial to consider the possible influence of anesthetic agents on esophageal function testing. Dexmedetomidine has been shown to affect primary peristalsis during esophageal manometry. In the two case reports presented by Toaz et al., secondary peristalsis during FLIP panometry was also affected. This may be attributed to an alternate pharmacodynamic effect, with a transient direct alpha 2-mediated effect on esophageal smooth muscle, associated with a high plasma concentration following bolus injection, prior to the onset of sympathetic inhibition.
It is crucial to consider the possible influence of anesthetic agents on esophageal function testing. Dexmedetomidine has been shown to affect primary peristalsis during esophageal manometry. In the two case reports presented by Toaz et al., secondary peristalsis during FLIP panometry was also affected. This may be attributed to an alternate pharmacodynamic effect, with a transient direct alpha 2-mediated effect on esophageal smooth muscle, associated with a high plasma concentration following bolus injection, prior to the onset of sympathetic inhibition.
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