Middle age self-report risk score predicts cognitive functioning and dementia in 20–40 years



: Eero Vuoksimaa,Juha O. Rinne,Noora Lindgren,Kauko Heikkilä,Markku Koskenvuo,Jaakko Kaprio

Publisher: [Amsterdam] : Elsevier B.V., [2015]-

: 2016

: Alzheimer's & dementia: diagnosis, assessment & disease monitoring

: 4

: 14

: 118

: 125

DOI: https://doi.org/10.1016/j.dadm.2016.08.003

: https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1016/j.dadm.2016.08.003

: https://research.utu.fi/converis/portal/detail/Publication/18026992


Introduction: On the basis of the proxy measures of cognitive reserve, we created a middle age self-report risk score for early prediction of dementia.
Methods: We used a longitudinal population-based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of 47 years was based on questions on educational and occupational attainments. Cognitive status at a mean age of 74 was determined via two validated telephone instruments.
Results: The prevalence of dementia was 10% after a mean follow-up of 28 years. Risk score was a good predictor of dementia: area under the curve = 0.77 (95% confidence interval, 0.74–0.80). The risk of dementia decreased as a function of risk score from 36% to 0%. The risk score was significantly associated with cognition after a mean follow-up of 39 years in the replication sample.
Discussion: Self-report risk score predicted cognitive functioning and dementia risk 20–40 years later.

Last updated on 2024-26-11 at 21:47