A1 Refereed original research article in a scientific journal
Middle age self-report risk score predicts cognitive functioning and dementia in 20–40 years
Authors: Eero Vuoksimaa,Juha O. Rinne,Noora Lindgren,Kauko Heikkilä,Markku Koskenvuo,Jaakko Kaprio
Publisher: [Amsterdam] : Elsevier B.V., [2015]-
Publication year: 2016
Journal: Alzheimer's & dementia: diagnosis, assessment & disease monitoring
Volume: 4
Issue: 14
First page : 118
Last page: 125
DOI: https://doi.org/10.1016/j.dadm.2016.08.003
Web address : https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1016/j.dadm.2016.08.003
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/18026992
Introduction: On the basis of the proxy measures of cognitive reserve, we created a middle age self-report risk score for early prediction of dementia.
Methods: We used a longitudinal population-based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of 47 years was based on questions on educational and occupational attainments. Cognitive status at a mean age of 74 was determined via two validated telephone instruments.
Results: The prevalence of dementia was 10% after a mean follow-up of 28 years. Risk score was a good predictor of dementia: area under the curve = 0.77 (95% confidence interval, 0.74–0.80). The risk of dementia decreased as a function of risk score from 36% to 0%. The risk score was significantly associated with cognition after a mean follow-up of 39 years in the replication sample.
Discussion: Self-report risk score predicted cognitive functioning and dementia risk 20–40 years later.
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