A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Photodissociation of bromine-substituted nitroimidazole radiosensitizers
Tekijät: Pihlava Lassi, Berholts Marta, Niskanen Johannes, Vladyka Anton, Kooser Kuno, Stråhlman Christian, Eng-Johnsson Per, Kivimäki Antti, Kukk Edwin
Kustantaja: Royal Society of Chemistry
Julkaisuvuosi: 2023
Journal: Physical Chemistry Chemical Physics
Vuosikerta: 25
Numero: 18
Aloitussivu: 13004
Lopetussivu: 13011
eISSN: 1463-9084
DOI: https://doi.org/10.1039/D2CP04888D
Verkko-osoite: https://doi.org/10.1039/D2CP04888D
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/179460510
Heavy elements and some nitroimidazoles both exhibit radiosensitizing properties through different mechanisms. In an effort to see how the overall radiosensitivity might be affected when the two radiosensitizers are combined in the same molecule, we studied the gas-phase photodissociation of two brominated nitroimidazoles and a bromine-free reference sample. Synchrotron radiation was employed to initiate the photodynamics and energy-resolved multiparticle coincidence spectroscopy was used to study the ensuing dissociation. We observed the brominated samples releasing high amounts of potentially radiosensitizing fragments upon dissociation. Since bromination also increases the likelihood of the drug molecule being ionised per a given X-ray dose, we conclude that heavy-element substitution of nitroimidazoles appears to be a viable path towards new, potent radiosensitizer drugs.
Ladattava julkaisu This is an electronic reprint of the original article. |