A1 Refereed original research article in a scientific journal
Photodissociation of bromine-substituted nitroimidazole radiosensitizers
Authors: Pihlava Lassi, Berholts Marta, Niskanen Johannes, Vladyka Anton, Kooser Kuno, Stråhlman Christian, Eng-Johnsson Per, Kivimäki Antti, Kukk Edwin
Publisher: Royal Society of Chemistry
Publication year: 2023
Journal: Physical Chemistry Chemical Physics
Volume: 25
Issue: 18
First page : 13004
Last page: 13011
eISSN: 1463-9084
DOI: https://doi.org/10.1039/D2CP04888D
Web address : https://doi.org/10.1039/D2CP04888D
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/179460510
Heavy elements and some nitroimidazoles both exhibit radiosensitizing properties through different mechanisms. In an effort to see how the overall radiosensitivity might be affected when the two radiosensitizers are combined in the same molecule, we studied the gas-phase photodissociation of two brominated nitroimidazoles and a bromine-free reference sample. Synchrotron radiation was employed to initiate the photodynamics and energy-resolved multiparticle coincidence spectroscopy was used to study the ensuing dissociation. We observed the brominated samples releasing high amounts of potentially radiosensitizing fragments upon dissociation. Since bromination also increases the likelihood of the drug molecule being ionised per a given X-ray dose, we conclude that heavy-element substitution of nitroimidazoles appears to be a viable path towards new, potent radiosensitizer drugs.
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