Radiotherapy Increases aMMP-8-Levels and Neutrophil/Lymphocyte Ratio Rapidly in Head and Neck Cancer Patients: A Pilot Study
: Brandt Ella, Keskin Mutlu, Tervahartiala Taina, Yılmaz Mustafa, Harmankaya İlknur, Karaçetin Didem, İpek Turgut, Gürsoy Ulvi Kahraman, Rautava Jaana, Gupta Shipra, Hagström Jaana, Räisänen Ismo T, Sorsa Timo
Publisher: Sage
: 2023
: Cancer Control : Journal of the Moffitt Cancer Center
: Cancer control : journal of the Moffitt Cancer Center
: Cancer Control
: 30
: 1073-2748
: 1526-2359
DOI: https://doi.org/10.1177/10732748231163653
: https://doi.org/10.1177/107327482311636
: https://research.utu.fi/converis/portal/detail/Publication/179435332
Radiotherapy for head and neck carcinoma (HNC) has both curative and palliative purposes. This study investigated mouthrinse aMMP-8 levels, molecular forms of MMP-8, blood neutrophil counts and neurophil/lymphocyte ratios before and 3 weeks after HNC radiotherapy started. Thirteen HNC patients undergoing radiotherapy were included. Mouthrinse samples (before and 3 weeks after HNC radiotherapy had started) were assayed quantitatively by aMMP-8 point-of-care-kit (PerioSafe®/ORALyzer®) and by western immunoblot. Total neutrophil counts and neutrophil/lymphocyte ratios were evaluated in the hemogram results. Three weeks after HNC radiotherapy started, significant increases in aMMP-8 levels and neutrophil/lymphocyte ratios were observed. No significant difference was found in total neutrophil counts. Elevations of the activated and fragmented MMP-8 levels after HNC radiotherapy application were observed on western immunoblot analysis. The increase in the aMMP-8 levels and neutrophil/lymphocyte ratios indicate inflammation both locally and systemically suggesting increased risk for periodontitis due to the HNC radiotherapy.
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