Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives
: Belibasakis Georgios N., Belstrøm Daniel, Eick Sigrun, Gursoy Ulvi K., Johansson Anders, Könönen Eija
Publisher: WILEY
: 2023
: Periodontology 2000
: PERIODONTOLOGY 2000
: PERIODONTOL 2000
: 17
: 0906-6713
: 1600-0757
DOI: https://doi.org/10.1111/prd.12473
: https://onlinelibrary.wiley.com/doi/10.1111/prd.12473
: https://research.utu.fi/converis/portal/detail/Publication/178885581
This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis-centered interpretation. Reference is made to anerobic microbiology and to the discovery of select periodontal pathogens and their virulence factors, as well as to biofilms. The evolution of contemporary molecular methods and high-throughput platforms is highlighted in appreciating the breadth and depth of the periodontal microbiome. Finally clinical microbiology is brought into perspective with the contribution of different microbial species in periodontal diagnosis, the combination of microbial and host biomarkers for this purpose, and the use of antimicrobials in the treatment of the disease.
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