Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia

: Rytkönen Kalle T, Adossa Nigatu, Mahmoudian Mehrad, Lönnberg Tapio, Poutanen Matti, Elo Laura L

Publisher: BIOSCIENTIFICA LTD

: 2022

: Reproduction

: REPRODUCTION

: 164

: 5

: V9

: V13

: 5

: 1470-1626

: 1741-7899

DOI: https://doi.org/10.1530/REP-22-0079(external)

: http://dx.doi.org/10.1530%2FREP-22-0079(external)

: https://research.utu.fi/converis/portal/detail/Publication/178040409(external)

In brief: Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia. Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.

Rytkonen2022_Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia.pdf