Associations of sedentary time, physical activity, and fitness with muscle glucose uptake in adults with metabolic syndrome
: Garthwaite Taru, Sjöros Tanja, Laine Saara, Koivumäki Mikko, Vähä-Ypyä Henri, Eskola Olli, Rajander Johan, Kallio Petri, Saarenhovi Maria, Löyttyniemi Eliisa, Sievänen Harri, Houttu Noora, Laitinen Kirsi, Kalliokoski Kari, Vasankari Tommi, Knuuti Juhani, Heinonen Ilkka
Publisher: Wiley
: 2023
: Scandinavian Journal of Medicine and Science in Sports
: Scandinavian journal of medicine & science in sports
: Scand J Med Sci Sports
: 33
: 3
: 353
: 358
: 0905-7188
: 1600-0838
DOI: https://doi.org/10.1111/sms.14287
: https://doi.org/10.1111/sms.14287
: https://research.utu.fi/converis/portal/detail/Publication/177913291
Objective: The objective of the study was to investigate the associations of sedentary time, physical activity, and cardiorespiratory fitness with skeletal muscle glucose uptake (GU).
Methods: Sedentary time and physical activity were measured with accelerometers and VO2 max with cycle ergometry in 44 sedentary adults with metabolic syndrome. Thigh muscle GU was determined with [18 F]FDG-PET imaging.
Results: Sedentary time (β = -0.374), standing (β = 0.376), steps (β = 0.351), and VO2 max (β = 0.598) were associated with muscle GU when adjusted for sex, age, and accelerometer wear time. Adjustment for body fat-% turned all associations non-significant.
Conclusion: Body composition is a more important determinant of muscle GU in this population than sedentary time, physical activity, or fitness.
