A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Macroporous silicon-wollastonite scaffold with Sr/Se/Zn/Mg-substituted hydroxyapatite/chitosan hydrogel
Tekijät: Ressler Antonia, Kamboj Nikhil, Ledinski Maja, Rogina Anamarija, Urlić Inga, Hussainova Irina, Ivanković Hrvoje, Ivanković Marica
Kustantaja: Elsevier B.V.
Julkaisuvuosi: 2022
Journal: Open Ceramics
Tietokannassa oleva lehden nimi: Open Ceramics
Artikkelin numero: 100306
Vuosikerta: 12
eISSN: 2666-5395
DOI: https://doi.org/10.1016/j.oceram.2022.100306
Verkko-osoite: https://www.sciencedirect.com/science/article/pii/S266653952200089X?via%3Dihub
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/176836916
The scaffolds, which morphologically and physiologically mimic natural features of the bone, are of a high demand for regenerative medicine. To address this challenge, bioactive porous silicon/wollastonite (SC) scaffold has been developed for potential bone tissue engineering applications. Additive manufacturing through the selective laser melting approach has been exploited to fabricate computer-aided designed scaffolds with a pore size of 400 μm. To increase the biocompatibility and osteogenic properties of SC scaffolds, the hydrogel based on a mixture of four mono-substituted hydroxyapatites (sHAp) and biopolymer chitosan (CHT) has been incorporated into SC by impregnation and freeze-gelation method. The pore size of 400 μm of SC has provided enough space for the impregnation of polymer solution and composite (CHT/sHAp) suspension to form highly porous hydrogel within pores. By the combination of SC and CHT/sHAp, both cell attachment and homogeneous proliferation on SC scaffold as well as mechanical properties of CHT/sHAp hydrogel have been improved.
Ladattava julkaisu This is an electronic reprint of the original article. |