A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Macroporous silicon-wollastonite scaffold with Sr/Se/Zn/Mg-substituted hydroxyapatite/chitosan hydrogel




TekijätRessler Antonia, Kamboj Nikhil, Ledinski Maja, Rogina Anamarija, Urlić Inga, Hussainova Irina, Ivanković Hrvoje, Ivanković Marica

KustantajaElsevier B.V.

Julkaisuvuosi2022

JournalOpen Ceramics

Tietokannassa oleva lehden nimiOpen Ceramics

Artikkelin numero100306

Vuosikerta12

eISSN2666-5395

DOIhttps://doi.org/10.1016/j.oceram.2022.100306

Verkko-osoitehttps://www.sciencedirect.com/science/article/pii/S266653952200089X?via%3Dihub

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/176836916


Tiivistelmä

The scaffolds, which morphologically and physiologically mimic natural features of the bone, are of a high demand for regenerative medicine. To address this challenge, bioactive porous silicon/wollastonite (SC) scaffold has been developed for potential bone tissue engineering applications. Additive manufacturing through the selective laser melting approach has been exploited to fabricate computer-aided designed scaffolds with a pore size of 400 μm. To increase the biocompatibility and osteogenic properties of SC scaffolds, the hydrogel based on a mixture of four mono-substituted hydroxyapatites (sHAp) and biopolymer chitosan (CHT) has been incorporated into SC by impregnation and freeze-gelation method. The pore size of 400 μm of SC has provided enough space for the impregnation of polymer solution and composite (CHT/sHAp) suspension to form highly porous hydrogel within pores. By the combination of SC and CHT/sHAp, both cell attachment and homogeneous proliferation on SC scaffold as well as mechanical properties of CHT/sHAp hydrogel have been improved.


Ladattava julkaisu

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