Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy



: Yan JQ, Zou HX, Zhou WH, Yuan XW, Li ZJ, Ma XD, Liu C, Wang YH, Rosenholm JM, Cui WG, Qu XM, Zhang HB

Publisher: ROYAL SOC CHEMISTRY

: 2022

: Biomaterials Science

: BIOMATERIALS SCIENCE

: BIOMATER SCI-UK

: 10

: 15

: 4119

: 4125

: 7

: 2047-4830

: 2047-4849

DOI: https://doi.org/10.1039/d2bm00640e

: https://doi.org/10.1039/D2BM00640E

: https://research.utu.fi/converis/portal/detail/Publication/176143658


Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

Last updated on 2024-26-11 at 22:57