A1 Refereed original research article in a scientific journal

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy



Authors: Yan JQ, Zou HX, Zhou WH, Yuan XW, Li ZJ, Ma XD, Liu C, Wang YH, Rosenholm JM, Cui WG, Qu XM, Zhang HB

Publisher: ROYAL SOC CHEMISTRY

Publication year: 2022

Journal: Biomaterials Science

Journal name in source: BIOMATERIALS SCIENCE

Journal acronym: BIOMATER SCI-UK

Volume: 10

Issue: 15

First page : 4119

Last page: 4125

Number of pages: 7

ISSN: 2047-4830

eISSN: 2047-4849

DOI: https://doi.org/10.1039/d2bm00640e

Web address : https://doi.org/10.1039/D2BM00640E

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/176143658


Abstract
Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

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Last updated on 2024-26-11 at 22:57