Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor



: Maatta JA, Olli K, Henttinen T, Tuittila MT, Elenius K, Salmivirta M

Publisher: BIOMED CENTRAL LTD

: 2009

: BMC Cell Biology

: BMC CELL BIOLOGY

: BMC CELL BIOL

: 10

: 7

: 1471-2121

DOI: https://doi.org/10.1186/1471-2121-10-5


Conclusion: In this communication, we suggest a novel role for cell surface heparan sulfate. Removal of cell surface heparan sulfate led to increased formation of ErbB4 intracellular domain. As ErbB4 intracellular domain has previously been shown to promote cell survival this finding may indicate a novel mechanism how HS degradation active in tumor tissue may favor cell survival.



Last updated on 2024-26-11 at 21:37