A1 Refereed original research article in a scientific journal
Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor
Authors: Maatta JA, Olli K, Henttinen T, Tuittila MT, Elenius K, Salmivirta M
Publisher: BIOMED CENTRAL LTD
Publication year: 2009
Journal: BMC Cell Biology
Journal name in source: BMC CELL BIOLOGY
Journal acronym: BMC CELL BIOL
Volume: 10
Number of pages: 7
ISSN: 1471-2121
DOI: https://doi.org/10.1186/1471-2121-10-5
Abstract
Conclusion: In this communication, we suggest a novel role for cell surface heparan sulfate. Removal of cell surface heparan sulfate led to increased formation of ErbB4 intracellular domain. As ErbB4 intracellular domain has previously been shown to promote cell survival this finding may indicate a novel mechanism how HS degradation active in tumor tissue may favor cell survival.
Conclusion: In this communication, we suggest a novel role for cell surface heparan sulfate. Removal of cell surface heparan sulfate led to increased formation of ErbB4 intracellular domain. As ErbB4 intracellular domain has previously been shown to promote cell survival this finding may indicate a novel mechanism how HS degradation active in tumor tissue may favor cell survival.
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