A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor
Tekijät: Maatta JA, Olli K, Henttinen T, Tuittila MT, Elenius K, Salmivirta M
Kustantaja: BIOMED CENTRAL LTD
Julkaisuvuosi: 2009
Journal: BMC Cell Biology
Tietokannassa oleva lehden nimi: BMC CELL BIOLOGY
Lehden akronyymi: BMC CELL BIOL
Vuosikerta: 10
Sivujen määrä: 7
ISSN: 1471-2121
DOI: https://doi.org/10.1186/1471-2121-10-5
Tiivistelmä
Conclusion: In this communication, we suggest a novel role for cell surface heparan sulfate. Removal of cell surface heparan sulfate led to increased formation of ErbB4 intracellular domain. As ErbB4 intracellular domain has previously been shown to promote cell survival this finding may indicate a novel mechanism how HS degradation active in tumor tissue may favor cell survival.
Conclusion: In this communication, we suggest a novel role for cell surface heparan sulfate. Removal of cell surface heparan sulfate led to increased formation of ErbB4 intracellular domain. As ErbB4 intracellular domain has previously been shown to promote cell survival this finding may indicate a novel mechanism how HS degradation active in tumor tissue may favor cell survival.
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