A1 Refereed original research article in a scientific journal
Schizophrenia polygenic risk score and long-term success in the labour market: A cohort study
Authors: Viinikainen Jutta, Böckerman Petri, Hakulinen Christian, Kari Jaana T, Lehtimäki Terho, Raitakari Olli T, Pehkonen Jaakko
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication year: 2022
Journal: Journal of Psychiatric Research
Journal name in source: JOURNAL OF PSYCHIATRIC RESEARCH
Journal acronym: J PSYCHIATR RES
Volume: 151
First page : 638
Last page: 641
Number of pages: 4
ISSN: 0022-3956
eISSN: 1879-1379
DOI: https://doi.org/10.1016/j.jpsychires.2022.05.041
Web address : https://www.sciencedirect.com/science/article/pii/S0022395622002941
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/175741642
Employment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance. We studied how the polygenic risk score (PGS) for schizophrenia related to education and labour market outcomes. We found that a higher PGS was linked to lower educational levels and weaker labour market outcomes as well as a higher likelihood of receiving social income transfers, particularly among men. Assuming that the link is causal, our results indicate that individuals with schizophrenia or schizophrenia-related traits have a weakened ability to fully participate in the labour market, potentially reinforcing social exclusion.
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