A1 Refereed original research article in a scientific journal
Weight gain in infancy and markers of cardiometabolic health in young adulthood
Authors: Nummela Saga R, Salo Pia, Pahkala Katja, Raitakari Olli T, Viikari Jorma, Rönnemaa Tapani, Jula Antti, Rovio Suvi P, Niinikoski Harri
Publisher: WILEY
Publication year: 2022
Journal: Acta Paediatrica
Journal name in source: ACTA PAEDIATRICA
Journal acronym: ACTA PAEDIATR
Volume: 11
Issue: 8
First page : 1603
Last page: 1611
Number of pages: 9
ISSN: 0803-5253
DOI: https://doi.org/10.1111/apa.16349
Web address : https://doi.org/10.1111/apa.16349
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/175199881
Aim We studied whether repeatedly measured weight gain from birth up to age 2 years associated with cardiometabolic health in young adulthood. Methods Using the data collected in the longitudinal Special Turku Coronary Risk Factor Intervention Project, we investigated in 454 healthy subjects how early weight gain in six age intervals (birth to 7 months, 7-13 months, 13-18 months, 18-24 months, and birth to 13 and 24 months) associated with measures of cardiometabolic health at age 20 years. Linear regression analyses were controlled for (1) child's sex, intervention/control group, gestational age, baseline weight and change in length for each interval, and (2) parents' education, mother's weight before pregnancy, height and weight gain during pregnancy, and father's body mass index at the 7-month visit. Results Weight gain after the first year of life associated directly, when adjusted for traits of the child and parents, with systolic blood pressure, waist circumference and body mass index at age 20 years. In the fully adjusted analyses, weight gain from birth to 1 year and to 2 years of age associated inversely with insulin and insulin resistance. We found no association between early growth and diastolic blood pressure or serum lipids. Conclusion Early weight gain during first 2 years of life may predict later markers of cardiometabolic health.
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