A2 Refereed review article in a scientific journal
Genetic, Molecular, and Cellular Determinants of Sex-Specific Cardiovascular Traits
Authors: Vaura Felix, Palmu Joonatan, Aittokallio Jenni, Kauko Anni, Niiranen Teemu
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Publication year: 2022
Journal: Circulation Research
Journal name in source: CIRCULATION RESEARCH
Journal acronym: CIRC RES
Volume: 130
Issue: 4
First page : 611
Last page: 631
Number of pages: 21
ISSN: 0009-7330
DOI: https://doi.org/10.1161/CIRCRESAHA.121.319891
Web address : https://doi.org/10.1161/CIRCRESAHA.121.319891
Abstract
Despite the well-known sex dimorphism in cardiovascular disease traits, the exact genetic, molecular, and cellular underpinnings of these differences are not well understood. A growing body of evidence currently points at the links between cardiovascular disease traits and the genome, epigenome, transcriptome, and metabolome. However, the sex-specific differences in these links remain largely unstudied due to challenges in bioinformatic methods, inadequate statistical power, analytic costs, and paucity of valid experimental models. This review article provides an overview of the literature on sex differences in genetic architecture, heritability, epigenetic changes, transcriptomic signatures, and metabolomic profiles in relation to cardiovascular disease traits. We also review the literature on the associations between sex hormones and cardiovascular disease traits and discuss the potential mechanisms underlying these associations, focusing on human studies.
Despite the well-known sex dimorphism in cardiovascular disease traits, the exact genetic, molecular, and cellular underpinnings of these differences are not well understood. A growing body of evidence currently points at the links between cardiovascular disease traits and the genome, epigenome, transcriptome, and metabolome. However, the sex-specific differences in these links remain largely unstudied due to challenges in bioinformatic methods, inadequate statistical power, analytic costs, and paucity of valid experimental models. This review article provides an overview of the literature on sex differences in genetic architecture, heritability, epigenetic changes, transcriptomic signatures, and metabolomic profiles in relation to cardiovascular disease traits. We also review the literature on the associations between sex hormones and cardiovascular disease traits and discuss the potential mechanisms underlying these associations, focusing on human studies.
UTU Research Portal