A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Genetic, Molecular, and Cellular Determinants of Sex-Specific Cardiovascular Traits
Tekijät: Vaura Felix, Palmu Joonatan, Aittokallio Jenni, Kauko Anni, Niiranen Teemu
Kustantaja: LIPPINCOTT WILLIAMS & WILKINS
Julkaisuvuosi: 2022
Journal: Circulation Research
Tietokannassa oleva lehden nimi: CIRCULATION RESEARCH
Lehden akronyymi: CIRC RES
Vuosikerta: 130
Numero: 4
Aloitussivu: 611
Lopetussivu: 631
Sivujen määrä: 21
ISSN: 0009-7330
DOI: https://doi.org/10.1161/CIRCRESAHA.121.319891
Verkko-osoite: https://doi.org/10.1161/CIRCRESAHA.121.319891
Tiivistelmä
Despite the well-known sex dimorphism in cardiovascular disease traits, the exact genetic, molecular, and cellular underpinnings of these differences are not well understood. A growing body of evidence currently points at the links between cardiovascular disease traits and the genome, epigenome, transcriptome, and metabolome. However, the sex-specific differences in these links remain largely unstudied due to challenges in bioinformatic methods, inadequate statistical power, analytic costs, and paucity of valid experimental models. This review article provides an overview of the literature on sex differences in genetic architecture, heritability, epigenetic changes, transcriptomic signatures, and metabolomic profiles in relation to cardiovascular disease traits. We also review the literature on the associations between sex hormones and cardiovascular disease traits and discuss the potential mechanisms underlying these associations, focusing on human studies.
Despite the well-known sex dimorphism in cardiovascular disease traits, the exact genetic, molecular, and cellular underpinnings of these differences are not well understood. A growing body of evidence currently points at the links between cardiovascular disease traits and the genome, epigenome, transcriptome, and metabolome. However, the sex-specific differences in these links remain largely unstudied due to challenges in bioinformatic methods, inadequate statistical power, analytic costs, and paucity of valid experimental models. This review article provides an overview of the literature on sex differences in genetic architecture, heritability, epigenetic changes, transcriptomic signatures, and metabolomic profiles in relation to cardiovascular disease traits. We also review the literature on the associations between sex hormones and cardiovascular disease traits and discuss the potential mechanisms underlying these associations, focusing on human studies.
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