A1 Refereed original research article in a scientific journal
Preconceptual leptin levels in gestational diabetes and hypertensive pregnancy
Authors: Peltokorpi Antti, Lisinen Irina, Viikari Liisa, Kaaja Risto
Publisher: TAYLOR & FRANCIS INC
Publication year: 2022
Journal: Hypertension in Pregnancy
Journal name in source: HYPERTENSION IN PREGNANCY
Journal acronym: HYPERTENS PREGNANCY
Volume: 41
Issue: 1
First page : 70
Last page: 77
Number of pages: 8
ISSN: 1064-1955
DOI: https://doi.org/10.1080/10641955.2022.2033763
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/174865307
Pregnancy - induced hypertension (PIH), preeclampsia (PE), and gestational diabetes (GDM) are common adverse outcomes in pregnancy.
Objective
To find out whether preconceptual leptin levels differ in subsequent pregnancy between control vs. GDM and hypertensive pregnancy groups.
Materials and Methods
Data was from The Cardiovascular Risk in Young Finns Study and The Medical Birth Register of Finland. Of 293 subjects 71 developed GDM, 27 PIH/PE and 201 were controls.
Results
Leptin was higher in GDM (p < 0.0001) and PIH/PE (p = 0.0002) groups compared to control. GDM group was robust to BMI matching (p = 0,0081).
Conclusion
Leptin was higher in GDM (p < 0.0001) and PIH/PE (p = 0.0002) groups compared to control. GDM group was robust to BMI matching (p = 0,0081).
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