Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes



: Anastasina M, Le May N, Bugai A, Fu Y, Soderholm S, Gaelings L, Ohman T, Tynell J, Kyttanen S, Barboric M, Nyman TA, Matikainen S, Julkunen I, Butcher SJ, Egly JM, Kainov DE

Publisher: ELSEVIER SCIENCE BV

: 2016

: BBA - Gene Regulatory Mechanisms

: BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS

: BBA-GENE REGUL MECH

: 1859

: 11

: 1440

: 1448

: 9

: 1874-9399

DOI: https://doi.org/10.1016/j.bbagrm.2016.09.005


Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. (C) 2016 Elsevier B.V. All rights reserved.



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