A1 Refereed original research article in a scientific journal
Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes
Authors: Anastasina M, Le May N, Bugai A, Fu Y, Soderholm S, Gaelings L, Ohman T, Tynell J, Kyttanen S, Barboric M, Nyman TA, Matikainen S, Julkunen I, Butcher SJ, Egly JM, Kainov DE
Publisher: ELSEVIER SCIENCE BV
Publication year: 2016
Journal: BBA - Gene Regulatory Mechanisms
Journal name in source: BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Journal acronym: BBA-GENE REGUL MECH
Volume: 1859
Issue: 11
First page : 1440
Last page: 1448
Number of pages: 9
ISSN: 1874-9399
DOI: https://doi.org/10.1016/j.bbagrm.2016.09.005
Abstract
Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. (C) 2016 Elsevier B.V. All rights reserved.
Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. (C) 2016 Elsevier B.V. All rights reserved.
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