A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes
Tekijät: Anastasina M, Le May N, Bugai A, Fu Y, Soderholm S, Gaelings L, Ohman T, Tynell J, Kyttanen S, Barboric M, Nyman TA, Matikainen S, Julkunen I, Butcher SJ, Egly JM, Kainov DE
Kustantaja: ELSEVIER SCIENCE BV
Julkaisuvuosi: 2016
Journal: BBA - Gene Regulatory Mechanisms
Tietokannassa oleva lehden nimi: BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
Lehden akronyymi: BBA-GENE REGUL MECH
Vuosikerta: 1859
Numero: 11
Aloitussivu: 1440
Lopetussivu: 1448
Sivujen määrä: 9
ISSN: 1874-9399
DOI: https://doi.org/10.1016/j.bbagrm.2016.09.005
Tiivistelmä
Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. (C) 2016 Elsevier B.V. All rights reserved.
Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. (C) 2016 Elsevier B.V. All rights reserved.
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