Immunological Reconstitution in Children After Completing Conventional Chemotherapy of Acute Lymphoblastic Leukemia is Marked by Impaired B-cell Compartment



: Koskenvuo M, Ekman I, Saha E, Salokannel E, Matomaki J, Ilonen J, Kainulainen L, Arola M, Lahteenmaki PM

Publisher: WILEY-BLACKWELL

: 2016

: Pediatric Blood and Cancer

: PEDIATRIC BLOOD & CANCER

: PEDIATR BLOOD CANCER

: 63

: 9

: 1653

: 1656

: 4

: 1545-5009

DOI: https://doi.org/10.1002/pbc.26047

: https://research.utu.fi/converis/portal/detail/Publication/17342154


Humoral and cellular immunity were studied in 28 children completing conventional treatment of standard-risk (SR) or intermediate-risk (IR) acute lymphoblastic leukemia (ALL). Both naive and memory B cells were most severely affected and showed slow recovery during the 2-year follow-up, while the T-cell compartment showed only minor changes. Immunoglobulins and IgG subclasses, components, and antibodies against vaccine-preventable diseases were not significantly affected. In conclusion, immune recovery after conventional chemotherapy for SR and IR ALL is marked by B-cell depletion, but otherwise did not show any severe deficiencies in lymphocyte function. (C) 2016 Wiley Periodicals, Inc.

Last updated on 2024-26-11 at 23:40