A1 Refereed original research article in a scientific journal
Immunological Reconstitution in Children After Completing Conventional Chemotherapy of Acute Lymphoblastic Leukemia is Marked by Impaired B-cell Compartment
Authors: Koskenvuo M, Ekman I, Saha E, Salokannel E, Matomaki J, Ilonen J, Kainulainen L, Arola M, Lahteenmaki PM
Publisher: WILEY-BLACKWELL
Publication year: 2016
Journal: Pediatric Blood and Cancer
Journal name in source: PEDIATRIC BLOOD & CANCER
Journal acronym: PEDIATR BLOOD CANCER
Volume: 63
Issue: 9
First page : 1653
Last page: 1656
Number of pages: 4
ISSN: 1545-5009
DOI: https://doi.org/10.1002/pbc.26047
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/17342154
Humoral and cellular immunity were studied in 28 children completing conventional treatment of standard-risk (SR) or intermediate-risk (IR) acute lymphoblastic leukemia (ALL). Both naive and memory B cells were most severely affected and showed slow recovery during the 2-year follow-up, while the T-cell compartment showed only minor changes. Immunoglobulins and IgG subclasses, components, and antibodies against vaccine-preventable diseases were not significantly affected. In conclusion, immune recovery after conventional chemotherapy for SR and IR ALL is marked by B-cell depletion, but otherwise did not show any severe deficiencies in lymphocyte function. (C) 2016 Wiley Periodicals, Inc.
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