Cannabinor, a Selective Cannabinoid-2 Receptor Agonist, Improves Bladder Emptying in Rats With Partial Urethral Obstruction



: Gratzke C, Streng T, Stief CG, Alroy I, Limberg BJ, Downs TR, Rosenbaum JS, Hedlund P, Andersson KE

Publisher: ELSEVIER SCIENCE INC

: 2011

: Journal of Urology

: JOURNAL OF UROLOGY

: J UROLOGY

: 2

: 185

: 2

: 731

: 736

: 6

: 0022-5347

DOI: https://doi.org/10.1016/j.juro.2010.09.080


Conclusions: In rats with partial urethral obstruction treated daily for 14 days with cannabinor bladder weight was lower, the ability to empty the bladder was preserved and nonvoiding contraction frequency was low compared to those in controls. Detrusor preparations from cannabinor treated rats showed a higher response to nerve stimulation than those from controls. Selective cannabinoid 2 receptor activation may be a novel principle to enable improved bladder function after partial urethral obstruction.



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