A1 Refereed original research article in a scientific journal
Cannabinor, a Selective Cannabinoid-2 Receptor Agonist, Improves Bladder Emptying in Rats With Partial Urethral Obstruction
Authors: Gratzke C, Streng T, Stief CG, Alroy I, Limberg BJ, Downs TR, Rosenbaum JS, Hedlund P, Andersson KE
Publisher: ELSEVIER SCIENCE INC
Publication year: 2011
Journal: Journal of Urology
Journal name in source: JOURNAL OF UROLOGY
Journal acronym: J UROLOGY
Number in series: 2
Volume: 185
Issue: 2
First page : 731
Last page: 736
Number of pages: 6
ISSN: 0022-5347
DOI: https://doi.org/10.1016/j.juro.2010.09.080
Abstract
Conclusions: In rats with partial urethral obstruction treated daily for 14 days with cannabinor bladder weight was lower, the ability to empty the bladder was preserved and nonvoiding contraction frequency was low compared to those in controls. Detrusor preparations from cannabinor treated rats showed a higher response to nerve stimulation than those from controls. Selective cannabinoid 2 receptor activation may be a novel principle to enable improved bladder function after partial urethral obstruction.
Conclusions: In rats with partial urethral obstruction treated daily for 14 days with cannabinor bladder weight was lower, the ability to empty the bladder was preserved and nonvoiding contraction frequency was low compared to those in controls. Detrusor preparations from cannabinor treated rats showed a higher response to nerve stimulation than those from controls. Selective cannabinoid 2 receptor activation may be a novel principle to enable improved bladder function after partial urethral obstruction.
UTU Research Portal