A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Cannabinor, a Selective Cannabinoid-2 Receptor Agonist, Improves Bladder Emptying in Rats With Partial Urethral Obstruction
Tekijät: Gratzke C, Streng T, Stief CG, Alroy I, Limberg BJ, Downs TR, Rosenbaum JS, Hedlund P, Andersson KE
Kustantaja: ELSEVIER SCIENCE INC
Julkaisuvuosi: 2011
Journal: Journal of Urology
Tietokannassa oleva lehden nimi: JOURNAL OF UROLOGY
Lehden akronyymi: J UROLOGY
Numero sarjassa: 2
Vuosikerta: 185
Numero: 2
Aloitussivu: 731
Lopetussivu: 736
Sivujen määrä: 6
ISSN: 0022-5347
DOI: https://doi.org/10.1016/j.juro.2010.09.080
Tiivistelmä
Conclusions: In rats with partial urethral obstruction treated daily for 14 days with cannabinor bladder weight was lower, the ability to empty the bladder was preserved and nonvoiding contraction frequency was low compared to those in controls. Detrusor preparations from cannabinor treated rats showed a higher response to nerve stimulation than those from controls. Selective cannabinoid 2 receptor activation may be a novel principle to enable improved bladder function after partial urethral obstruction.
Conclusions: In rats with partial urethral obstruction treated daily for 14 days with cannabinor bladder weight was lower, the ability to empty the bladder was preserved and nonvoiding contraction frequency was low compared to those in controls. Detrusor preparations from cannabinor treated rats showed a higher response to nerve stimulation than those from controls. Selective cannabinoid 2 receptor activation may be a novel principle to enable improved bladder function after partial urethral obstruction.
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