Nucleic acids through condensation of nucleosides and phosphorous acid in the presence of sulfur




Lonnberg T

PublisherBEILSTEIN-INSTITUT

2016

Beilstein Journal of Organic Chemistry

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

BEILSTEIN J ORG CHEM

12

670

673

4

1860-5397

DOIhttps://doi.org/10.3762/bjoc.12.67



Short phosphorothioate oligonucleotides have been prepared by refluxing an equimolar mixture of thymidine and triethylammonium phosphite in toluene in the presence of elemental sulfur. Desulfurization and subsequent digestion of the products by P1 nuclease revealed that nearly 80% of the internucleosidic linkages thus formed were of the canonical 3',5'-type.

Last updated on 2024-26-11 at 11:50